Microwave promoted one-pot synthesis of 3-(2′-amino-3′-cyano-4′-arylpyrid-6′-yl)coumarins

• 出 处: Chinese Chemical Letters
• 发表日期: 2009年01期
• 关键词: cyano amino-3 arylpyrid-6 cyano-4 yl)coumarins aldehydes irradiation aromatic fa

A facile procedure for the synthesis of 3-(2′-amino-3′-cyano-4′-arylpyrid-6′-yl)coumarins are being reported starting from 3- acetylcoumarin,aromatic aldehydes and malononitrile.The reactions were carded out on microwave irradiation in good yield with short time and easy work-up.The structures of all the compounds have been confirmed on the basis of their analytical,IR,~1H NMR, and mass spectral data.

A facile procedure for the synthesis of 3- (2’-amino-3’-cyano-4’-arylpyrid-6’- yl) coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile.The reactions were carded out on microwave irradiation in good yield with short time and easy work-up. The structures of all the compounds have been confirmed on the basis of their analytical, IR, ~ 1H NMR, and mass spectral data.