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肾病综合征(NS)患儿约75%为微小病变(MCD),长期随访发现该病的预后良好,其次为局灶节段性肾小球硬化(F3GS)预后较差。FSGS是否为MCD的延续或变异,抑或独立的临床病理形式尚有争论。许多研究显示,在这些疾病中与预后相关的形态学表现很少。有人发现,典型的MCD患者伴系膜细胞增殖常提示预后不良,FSGS的系膜细胞增殖,肾门区局灶硬化与肾功能恶化和预后不良有关。该文作者回顾性研究33例特发性NS患儿,经11年的随
About 75% of children with nephrotic syndrome (NS) have minimal change (MCD). Long-term follow-up found that the disease has a good prognosis, followed by poor prognosis in focal segmental glomerulosclerosis (F3GS). Whether or not FSGS is a continuation or mutation of MCD, or an independent clinical pathological form is still debated. Numerous studies have shown that there are few prognostic morphologic manifestations in these diseases. It was found that typical MCD patients with mesangial cell proliferation often prompted a poor prognosis, mesangial cell proliferation of FSGS, focal renal nephrosis and renal dysfunction and poor prognosis. The authors retrospectively studied 33 patients with idiopathic NS who had been followed for 11 years