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1931年Zimmermann首先报道,位于肾小球血管袢轴心、呈现结缔组织样的结构,称之为系膜。此后它就一直成为肾小球形态结构、功能及其病理改变研究的一个焦点。近10多年来,随着肾小球接种技术和单一、纯化的系膜细胞培养的成功,对其复杂的生物学特性,包括吞噬和收缩功能、基质蛋白和生长因子的合成和分泌、细胞增生和抑制的调节机理等研究,都取得了重大的进展。近几年来,人们又对其细胞表面各种多肽和脂质受体,以及受体激活后细胞内信号转导通道的
Zimmermann first reported in 1931, located in the glomerular angiosperm axis, presenting a connective tissue-like structure, called the mesangium. Since then it has been a focal point for the study of glomerular morphology, function and pathological changes. For nearly 10 years, with the success of glomerular inoculation technology and single, purified mesangial cell culture, its complex biological characteristics including phagocytic and contractile function, synthesis and secretion of matrix proteins and growth factors, cell proliferation And inhibition of the regulatory mechanism of research, have made significant progress. In recent years, people on its cell surface of various peptides and lipid receptors, as well as the activation of intracellular signal transduction channels