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目的:分析新生儿ABO溶血病的临床相关危险因素,提高对新生儿ABO溶血病的防治水平。方法:选择ABO血型不合的孕妇433例,根据以上产妇产前IgG抗A(B)效价、产妇妊娠次数和产妇年龄分别分组,分析各组产妇间发生新生儿溶血病(HDN)的差异及临床相关性。结果:产妇产前IgG抗A(B)效价、产妇妊娠次数和产妇年龄均与HDN发生率呈正相关性(P<0.05);IgG抗A(B)效价>256时,HDN发生率将显著提高(P<0.01);产妇妊娠次数和年龄增加后,HDN发生率将显著增加(P<0.01)。结论:夫妻血型不合的产妇进行产前保健时,应进行IgG抗A(B)效价检查,当IgG抗A(B)效价>64或IgG抗A(B)效价进行性增加时,应及早做好HDN的干预措施;通过减少意外妊娠及高龄产妇数量,可减少HDN的发生。
Objective: To analyze the clinically relevant risk factors of neonatal ABO hemolytic disease and to improve the prevention and treatment of neonatal ABO hemolytic disease. Methods: A total of 433 pregnant women with ABO blood group incompatibility were selected. The differences of neonatal hemolytic disease (HDN) among the three groups were analyzed according to the titer of prenatal IgG anti-A (B), maternal pregnancy and maternal age. Clinical relevance. Results: Prenatal IgG anti-A (B) titer, number of maternal pregnancies and maternal age were positively correlated with the incidence of HDN (P <0.05). The HDN incidence of IgG anti-A (B) (P <0.01). After the number and age of pregnant women increased, the incidence of HDN increased significantly (P <0.01). CONCLUSIONS: In prenatal care, males with different blood types should be tested for IgG anti-A (B) titer. When the titers of IgG anti-A (B)> 64 or IgG anti-A (B) HDN interventions should be done as soon as possible; HDN may be reduced by reducing the number of unwanted pregnancies and older mothers.