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钯催化剂是一类重要的金属催化剂,在有机合成中应用非常广泛.过去几十年里,钯催化的不对称反应也取得了巨大的成就,但是,对于卡宾转移这类非常重要的有机反应,很少有钯催化剂能够给出高对映选择性.最近,南开大学化学学院周其林和朱守非带领课题组实现了首例钯催化不对称O—H键插入反应,获得了很高的对映选择性(最高达到99%ee).这类钯催化不对称卡宾转移反应首次实现了重要手性砌块α-芳氧基苯乙酸衍生物的不对称催化合
Palladium catalysts are an important class of metal catalysts and are widely used in organic synthesis. Palladium-catalyzed asymmetric reactions have also achieved great success over the past few decades, but for the very important organic reactions such as carbene transfer, Few palladium catalysts give high enantioselectivities Recently, Zhou Qilin and Zhu Shoufei of the Faculty of Chemistry at Nankai University led the first palladium-catalyzed asymmetric O-H bond insertion with high enantioselectivity (Up to 99% ee.) This class of palladium-catalyzed asymmetric carbene transfer reactions has for the first time achieved the asymmetric catalysis of important chiral building block a-aryloxyphenylacetic acid derivatives