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二磷酸盐已广泛用于恶性肿瘤所致的高钙血症、骨纤维结构不良、朗格汉斯细胞增多症和急性粒细胞白血病等青少年疾病。近年来较多研究指出二磷酸盐尚有直接的抗肿瘤活性,而体外基础研究还显示,二膦酸盐无论是单用或是联合化疗都具有抗骨肉瘤活性。Memorial Sloan-Kettering癌症中心的Meyers等(Cancer 2011,8:1736-1744)开展了一项新的临床实验,入组了40例初治骨肉瘤患者(29例局限病灶、
Diphosphate has been widely used in malignancies such as hypercalcemia, bone fibrous dysplasia, Langerhans disease and acute myeloid leukemia and other adolescent diseases. In recent years, more studies have pointed out that there is direct anti-tumor activity of bisphosphonates, and basic research in vitro also showed that bisphosphonates either alone or in combination with chemotherapy have anti-osteosarcoma activity. Meyers et al (Cancer 2011, 8: 1736-1744) at the Memorial Sloan-Kettering Cancer Center conducted a new clinical trial enrolling 40 patients with newly diagnosed osteosarcoma (29 localized lesions,