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微小病变型肾病(MCN)是肾病综合征中最常见的一种类型,这类病人肾组织光镜检查缺乏明显的肾小球病变,对皮质激素和免疫抑制剂反应敏感,预后一般良好。部分病人虽可出现一过性血尿素氮和肌酐升高,但多系肾前因素(低血容量)所致,很少发生器质性肾功能衰竭。1966年Chamberlain等首次报告2例微小病变型肾病患者发生急性肾衰。之后这类病例陆续见诸文献,至目前已报告31例。现将有关资料介绍如下。
Minimal change nephropathy (MCN) is the most common type of nephrotic syndrome. Renal histopathology in these patients lacks obvious glomerular lesions and is responsive to corticosteroids and immunosuppressive agents with generally favorable prognosis. Although some patients may have a transient increase in blood urea nitrogen and creatinine, but more Department of pre-renal factors (hypovolemia) caused by seldom organic renal failure. In 1966, Chamberlain et al. First reported acute renal failure in 2 patients with minimal change nephropathy. After such cases have been seen in the literature, up to now have been reported in 31 cases. The relevant information is as follows.