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目的研究经蝶入路垂体瘤切除术的临床效果。方法回顾性分析2010年1月至2012年1月收治的89例经蝶入路切除垂体瘤的患者的临床资料,观察其手术方法、手术后疗效、手术前后生活质量和手术后并发症等。结果 89例患者中,显效70例(78.7%),好转13例(14.6%),无效6例(6.7%),总有效83例(93.3%)。与手术前相比,手术后患者的生活质量显著提高。手术后4例患者出现尿崩症状,对症治疗后均短期内恢复,其余并发症包括1例垂体功能低下,1例激素水平下降和1例脑脊液鼻漏,经对症治疗后均痊愈。结论单鼻孔经蝶入路治疗垂体瘤手术时间短,恢复快,疗效显著,手术后并发症较少。
Objective To study the clinical effect of transsphenoidal pituitary tumor resection. Methods The clinical data of 89 patients with pituitary adenoma who underwent transsphenoidal approach from January 2010 to January 2012 were retrospectively analyzed. The operative methods, postoperative efficacy, postoperative quality of life and postoperative complications were observed. Results Among 89 patients, 70 (78.7%) were significantly improved, 13 (14.6%) were improved, 6 (6.7%) were ineffective and 83 (93.3%) were effective. Compared with before surgery, the quality of life of patients after surgery significantly increased. After operation, 4 patients showed symptoms of diabetes insipidus. After the symptomatic treatment, they recovered within a short period of time. The remaining complications included 1 case of pituitary dysfunction, 1 case of hormone drop and 1 case of cerebrospinal fluid rhinorrhea. All patients recovered after symptomatic treatment. Conclusion Single nostril transsphenoidal approach for the treatment of pituitary tumor surgery time is short, rapid recovery, significant effect, less postoperative complications.