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目的调查分析宁波地区健康成人糖化血红蛋白(HbA1c)水平,探讨不同年龄和性别的健康成人HbA1c水平差异,并建立相应的参考范围。方法应用伯乐VARIANTⅡ糖化血红蛋白分析仪对7 890名健康成人进行HbA1c水平测定,比较不同年龄、不同性别组HbA1c水平的差异,采用百分位数建立健康成人HbA1c的参考范围(P2.5~P97.5)。结果不同年龄组间HbA1c水平的差异具有统计学意义。不同性别间,其中18岁~30岁年龄组HbA1c水平差异具有统计学意义,其余3个年龄组差异无统计学意义。18岁~30岁男性、女性HbA1c参考范围分别是4.80%~5.80%和4.70%~5.70%;成人31岁~45岁、46岁~60岁及≥61岁HbA1c参考范围分别是4.60%~5.90%、4.40%~6.20%和4.50%~6.30%。结论初步建立适合当地的HbA1c水平,为临床诊治提供良好依据。
Objective To investigate the levels of HbA1c in healthy adults in Ningbo and to explore the differences of HbA1c levels in healthy adults of different ages and genders and establish corresponding reference ranges. Methods The HbA1c levels of 7 890 healthy adults were determined by using VARIANT Ⅱ glycosylated hemoglobin analyzer. The differences of HbA1c levels in different age groups and genders were compared. The reference range (P2.5 ~ P97) of healthy adult HbA1c was established by percentile. 5). Results The differences of HbA1c levels among different age groups were statistically significant. The differences of HbA1c level between 18 and 30 years old were statistically significant among different genders, while there was no significant difference among the other three age groups. The reference ranges of HbA1c between 18 and 30 years old were 4.80% ~ 5.80% and 4.70% ~ 5.70% respectively. The reference ranges of HbA1c between 31 ~ 45, 46 ~ 60 and ≥61 years were 4.60% ~ 5.90 %, 4.40% ~ 6.20% and 4.50% ~ 6.30%. Conclusion The preliminary establishment of a suitable local HbA1c level provides a good basis for clinical diagnosis and treatment.