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Notch信号转导通路由一组在进化上高度保守的细胞膜配体、受体及下游分子组成。细胞间受体配体作用可激活Notch信号转导过程,从而直接调节基因转录,使细胞基因表达受相邻细胞调控,Notch信号在细胞分化、胚胎发育、组织自我更新过程中均发挥了重要的作用,许多病理过程(包括肿瘤)都有Notch信号参与。Notch信号多作为癌基因促进肿瘤生长,但在某些组织也可起到诱导细胞分化、抑制肿瘤增殖的作用。肿瘤干细胞中Notch信号的改变可能发挥了关键性作用。目前认为,Notch在肝癌中作为抑癌基因抑制肿瘤的生长,其机制初步被认为是Notch1使JNK活化、p53高表达以及Bcl-2表达下调,从而诱导肝癌细胞凋亡,但尚待更加深入的研究。鉴于针对Notch信号通路的干预措施已经成为治疗肿瘤的新方式,该通路也有望成为肝癌的生物治疗新的靶点。
Notch signal transduction pathway by a group of evolutionarily highly conserved cell membrane ligands, receptors and downstream molecules. The role of intercellular receptor ligand can activate Notch signal transduction process, which directly regulates gene transcription so that cell gene expression is regulated by neighboring cells. Notch signaling plays an important role in cell differentiation, embryonic development and tissue self-renewal Role, many pathological processes (including tumors) have Notch signal involved. Notch signaling as an oncogene promotes tumor growth, but in some tissues, it can also induce cell differentiation and inhibit tumor proliferation. Changes in Notch signaling in tumor stem cells may play a key role. At present, Notch suppresses tumor growth as a tumor suppressor gene in liver cancer. The mechanism of Notch is presumed to be that Notch1 activates JNK, high expression of p53 and down-regulation of Bcl-2, thereby inducing apoptosis of hepatoma cells. However, more in-depth the study. Given that interventions targeting the Notch signaling pathway have become new ways to treat tumors, the pathway is also expected to be a new target for biotherapeutics of HCC.