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对原发性肝细胞癌（PHC）、肝炎肝硬化及其它各种恶性肿瘤患者共419例进行血清a-L-岩藻糖苷酶（AFU）和甲胎蛋白（AFP）的测定，并以60名健康人作对照，结果PHC组的AFU活性（241．9±112．5）显著高于健康对照组（116．1±28．0）及其他各组（P＜0．01），AFU活性对PHC诊断的敏感性为69．6％，特异性为90．1％，AFU活性与AFP浓度间无明显相关性，AFP与AFU联合检测对PHC的诊断率可提高到89．6％，且随病情好转和恶化而下降和上升，提示检测血清AFU活性对PHC的诊断、疗效观察均有重要的临床价值。
A total of 419 patients with primary hepatocellular carcinoma (PHC), hepatitis cirrhosis, and other malignancies were tested for serum aL-fucosidase (AFU) and alpha-fetoprotein (AFP), and 60 healthy individuals. As a control, the AFU activity in the PHC group (241.9±112.5) was significantly higher than that in the healthy control group (116.1±28.0) and other groups (P<0.01). The AFU activity was in the PHC group. The diagnostic sensitivity was 69.6%, and the specificity was 90.1%. There was no significant correlation between AFU activity and AFP concentration. The combined detection of AFP and AFU could increase the diagnostic rate of PHC to 89.6% and follow the condition. The decrease and increase in the improvement and deterioration indicate that the detection of serum AFU activity has important clinical value for the diagnosis and curative effect observation of PHC.