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目的:探讨通脉止痛方与尼莫地平联合治疗偏头痛的临床疗效。方法:将62例偏头痛患者随机分为治疗组(n=40)与对照组(n=22),对照组患者给予尼莫地平40 mg,每日3次,口服,4周为1个疗程。治疗组患者在对照组治疗基础上给予通脉止痛方治疗,以方内各单味药颗粒剂混合开水冲服,每日一剂,分2次服,疗程15 d。比较两组患者临床治疗总有效率及治疗前后双侧大脑中动脉(MCA)的最大血流速度(Vs)。结果:治疗组总有效率为85%,对照组总有效率63.6%(P<0.05)。治疗后两组Vs均显著下降(P<0.01),治疗组更明显(P<0.01)。结论:通脉止痛方联合尼莫地平治疗偏头痛疗效显著。
Objective: To investigate the clinical effect of Tongmai Decoction and nimodipine in the treatment of migraine. Methods: Sixty-two migraineurs were randomly divided into treatment group (n = 40) and control group (n = 22). Patients in control group were given nimodipine 40 mg three times a day orally for 4 weeks for one course of treatment . Patients in the treatment group were treated with Tongmai Zhitong Recipe on the basis of the treatment of the control group. Each of the herbs in the recipe was mixed with boiling water and mixed with boiling water twice a day for 15 days. The total effective rate of treatment and the maximum blood flow velocity (Vs) of bilateral middle cerebral artery (MCA) before and after treatment were compared between the two groups. Results: The total effective rate was 85% in the treatment group and 63.6% in the control group (P <0.05). After treatment, the Vs in both groups were significantly decreased (P <0.01), the treatment group was more obvious (P <0.01). Conclusion: Tongmai Decoction combined with nimodipine is effective in treating migraine.