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对52例高血压病(EH)及20例正常人进行口服葡萄糖耐量和胰岛素释放试验,结果显示糖负荷后 EH 病人胰岛素和血糖曲线下面积(AUC)显著高于对照组,其中 EH 肥胖者 AUC 高于 EH 非肥胖者,Ⅰ、Ⅱ期 EH 病人 AUC 无显著差异,但明显低于Ⅲ期 EH 病人。此外,EH 肥胖和非肥胖两亚组空腹胰岛素和胰岛素峰值与收缩压均正相关,但非肥胖者的相关性高于肥胖者。本文提示 EH 病人存在糖负荷后胰岛素抵抗(IR)和高胰岛素血症(HIS),肥胖可加重 EH 病人 IR,IR 的程度与 EH 分期有关,IR 和 HIS 是引起高血压的独立危险因素。
Oral glucose tolerance and insulin release test were performed in 52 patients with essential hypertension (EH) and 20 normal subjects. The results showed that the area under the curve of insulin and blood glucose (AUC) was significantly higher in EH patients after glucose load than in control subjects. The AUC Higher than EH non-obese, Ⅰ, Ⅱ EH patients AUC no significant difference, but significantly lower than the Ⅲ EH patients. In addition, fasting insulin and insulin peak were positively correlated with systolic blood pressure in EH obese and non-obese subgroups, but nonobese patients were more associated with obesity. This article suggests that patients with EH have insulin resistance (IR) and hyperinsulinemia (HIS) after glucose loading. Obesity may aggravate IR in EH patients. The extent of IR is related to EH staging. IR and HIS are independent risk factors for hypertension.