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百日咳菌体菌苗效果至今仍是一个有争论的课题。这场争论可一直追溯到30年代所进行的第一次现场试验。虽然在40和50年代发达国家广泛应用百日咳菌苗,但其效果不一。60年代中期英国百日咳菌苗的效果降低到20%,因而在1968年不得不改变菌苗成分和浓度。70年代瑞典由于菌苗无效而宣布停止使用。百日咳菌体菌苗保护效果的差异是研究的方法学问题还是未知的生物学因素,尚不明了。作者复习了百日咳菌体菌苗历年来的现
The effect of pertussis mycobacterial vaccine is still a controversial issue to date. This debate can be traced back to the first field trial conducted in the 1930s. Although pertussis vaccine is widely used in developed countries in the 1940s and 1950s, its effect is mixed. The effect of the British pertussis vaccine was reduced to 20% in the mid-1960s, so the composition and concentration of the vaccine had to be changed in 1968. Sweden in the 1970s declared its cessation of use due to ineffective vaccine. Pertussis Bacterial vaccine differences in the protective effect of the study methodological problems or unknown biological factors, it is not clear. The author reviewed the Pertussis bacterin over the years now