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目的观察格雷司琼加甲氧氯普胺(胃复安)及地塞米松联用预防含顺铂的联合化疗所致的恶心、呕吐及其他毒副反应,并与单用格雷司琼比较。方法采用随机交叉、自身对照法,将接受化疗的患者,随机分为两组。A组第1周期用格雷司琼联合甲氧氯普胺及地塞米松,第2周期单用格雷司琼;B组与A组相反。结果格雷司琼加甲氧氯普胺及地塞米松第1￣6天恶心、呕吐的有效控制率均高于单用格雷司琼组,其中第3、4天差异有显著性(P<0.05)。结论格雷司琼加甲氧氯普胺及地塞米松可作为预防和控制含顺铂联合化疗所致恶心、呕吐的一线治疗方法。
Objective To observe the efficacy and safety of combination of glossetron plus metoclopramide and dexamethasone in the prevention of nausea, vomiting and other side effects caused by combination chemotherapy with cisplatin. Methods Randomized crossover and self-control method were randomly divided into two groups. The first cycle of group A was treated with grecquisition combined with metoclopramide and dexamethasone, the second cycle with only granisetron; group B and group A the opposite. Results The effective rates of nausea and vomiting in the first to sixth days after the treatment with grecquisition plus metoclopramide and dexamethasone were higher than those in the group receiving only the greinstone, with the difference between days 3 and 4 being significant (P <0.05 ). Conclusions Grebestron plus metoclopramide and dexamethasone can be used as a first-line treatment for the prevention and control of nausea and vomiting induced by cisplatin combined with chemotherapy.