噪声作业工人血浆热应激蛋白60抗体与心电图异常的关系研究

• 作 者: 姚惠琳 祁成 李毅 杨杪 陈胜 郑建如 杨秋玲 邬堂春
• 机 构: 东风汽车公司职业病防治所,东风汽车公司职业病防治所,郧阳医学院附属东风医院检验部,华中科技大学同济医学院公共卫生学院,华中科技大学同济医学院公共卫生学院,东风汽车公司职业病防治所,东风汽车公司职业病防
• 出 处: 中国全科医学
• 发表日期: 2004年14期
• 关键词: 噪声 HSP60抗体 心电图异常

目的　探讨噪声作业工人血浆热应激蛋白 (HSP) 6 0抗体与心电图异常之间的关系。方法　用Westernblot免疫印迹法测定噪声作业工人血浆HSP 6 0抗体水平。用多因素Logistic回归分析HSP 6 0抗体水平与心电图异常的关系。结果　心电图异常组噪声作业工人HSP6 0抗体阳性率为 15 4 % ,心电图正常组为 5 9% ,差别有显著性意义(P <0 0 1) ;在排除了常见心血管疾病危险因素的影响后 ,心电图异常与HSP6 0抗体之间仍然存在着较强联系。结论　血浆HSP6 0抗体可能是噪声作业工人心电图异常的危险因素。

Objective To investigate the relationship between plasma heat stress protein (HSP60) antibody and abnormal electrocardiogram (ECG) in noise workers. Methods Western blot was used to determine the plasma levels of HSP60 antibody in noise exposed workers. Multivariate logistic regression analysis of HSP60 antibody levels and ECG abnormalities. Results The positive rate of HSP60 antibody in noise-exposed workers with abnormal electrocardiogram was 15 4% and that of normal ECG was 59%, with significant difference (P 0 01). After excluding the influence of common cardiovascular disease risk factors , There is still a strong relationship between abnormal ECG and HSP60 antibody. Conclusion Plasma HSP60 antibody may be a risk factor for ECG abnormality in noise workers.