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产前铅暴露与精神分裂症合理的神经生物学联系为Pb2+是n-甲基-d-天门冬氨酸(N-methyl-d-aspartate,NMDA)受体(NMDAR)的拮抗剂,而该病的病理生理学基础是NMDAR机能的衰退。
The rational neurobiological link between prenatal exposure to lead and schizophrenia is that Pb2 + is an antagonist of NMDAR (NMDAR) The pathophysiology of the disease is based on the decline of NMDAR function.