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曾有报道,氨茶碱拮抗安定所诱导的镇静作用,因而对其可能产生的相互作用进行对照性研究。18名患者在外科脊髓或局部麻醉手术前预用安定(10mg,直肠给药)。一旦达到麻醉,即可静注安定来诱导和维持深度镇静。然后病人静注生理盐水或氨茶碱(20mg/ml)的注射液3ml。在注射后2小时内不断地观察其镇静程度。病人接受氨茶碱后的镇静程度比对照组轻,给药20分钟时,用氨茶碱的病人除一例外,其它均可进行交谈,而对照组却无一人如此。给药2小时后,
It has been reported that aminophylline antagonizes diazepam-induced sedation, and thus its possible interaction of controlled study. Eighteen patients were given diazepam (10 mg, rectally) prior to surgical spinal cord or local anesthesia surgery. Once anesthetized, intravenous stability can be induced and maintained deep sedation. Then the patient intravenous injection of saline or aminophylline (20mg / ml) injection 3ml. Within 2 hours after injection, the degree of sedation was continuously observed. Patients seized aminophylline sedation than the control group, 20 minutes of administration, with aminophylline patients with one exception, the other can be talked, but none of the control group so. Two hours after administration,