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目的探讨体内淋巴细胞微核形成与肠癌和肺癌患者肿瘤恶性程度的关系。方法随机抽取大肠癌、肺癌患者各一组,术前取外周血进行体内淋巴细胞微核试验检测,比较癌症患者体内自发微核形成与良性病变及健康人群对照组的差异。结果肺、大肠癌组微核率(MNF)与对照组相比,差异有统计学意义(P<0.01);随着患癌组分化程度降低及淋巴结转移率的增加,MNF明显上升。结论患者淋巴体内细胞微核形成与肺、大肠癌分化与转移密切相关,为癌者患者的术前恶性程度判断和高危人群筛查提供了一个有用的生物学标志物。
Objective To investigate the relationship between micronucleus formation in lymphocytes and malignancy of colorectal cancer and lung cancer in vivo. Methods One group of patients with colorectal cancer and lung cancer was randomly selected. Peripheral blood was collected before operation for detection of micronuclei in lymphocytes. The differences between spontaneous micronuclei and benign lesions in cancer patients and healthy controls were compared. Results The micronucleus rate (MNF) in lung and colorectal cancer group was significantly higher than that in control group (P <0.01). MNF was significantly increased with the decrease of the degree of cancer and the increase of lymph node metastasis. Conclusions The micronucleus formation in lymphoid cells is closely related to the differentiation and metastasis of lung and colorectal cancer. It provides a useful biomarker for judging the malignant degree of cancer patients and screening high-risk population.