论文部分内容阅读
目的比较奥美拉唑和雷贝拉唑对糜烂性食管炎患者短期临床效果,并探讨两者作为质子泵抑制剂(PPI)试验的诊断价值。方法选择临床有烧心、反酸、胸骨后灼痛等反流症状,且胃镜检查确诊为糜烂性食管炎的患者63例,随机分别给予奥美拉唑20mg,每天2次(A组,31例)或雷贝拉唑10mg,每天2次(B组,32例)口服1周。以反流的相关症状下降2个等级或由轻度降为无症状为PPI试验阳性作为诊断标准,第3天和第7天进行症状评分及统计学分析。结果治疗第3天B组症状评分明显低于A组(P<0.01)。A组第3天检出率明显低于B组(48.4%vs.87.5%)(P<0.01)。结论与奥美拉唑相比,临床短期给雷贝拉唑能够更加迅速缓解糜烂性食管炎症状,雷贝拉唑试验可以改良传统的奥美拉唑试验。
Objective To compare the short-term clinical effects of omeprazole and rabeprazole in patients with esophageal erosions and to explore the diagnostic value of both as proton pump inhibitor (PPI) test. Methods Sixty-three patients with reflux esophagitis who had heartburn, acid reflux and post-sternal burn, and 20 patients with erosive esophagitis diagnosed by gastroscopy were randomly assigned to receive omeprazole 20 mg twice daily (group A, n = 31) ) Or rabeprazole 10mg twice daily (group B, 32 cases) for 1 week. The symptoms were retrospectively decreased by 2 levels or mildly reduced to asymptomatic as PPI test positive as a diagnostic criteria, the first 3 days and 7 days for symptom score and statistical analysis. Results On the third day after treatment, the score of symptom in group B was significantly lower than that in group A (P <0.01). The detection rate of the third day in group A was significantly lower than that in group B (48.4% vs.87.5%) (P <0.01). Conclusions Compared with omeprazole, rabeprazole can shorten the erosive esophagitis symptom more rapidly in clinic, rabeprazole test can improve the traditional omeprazole test.