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【目的】比较淋巴管灌注化疗（ 实验组）与常规放疗或化疗（ 对照组） 治疗妇科癌 症淋巴结转移的临床疗效。【方法】２０ 例患者经足背淋巴管大剂量一次性灌注给药； 灌注前后根据患者病种测定 Ｓ Ａ 或 Ｃ Ａ１２５ 的水平和顺铂的血药浓度及淋巴结转移灶影 像学变化； 并比较常规放化疗方法， 其患者 的近期疗效和２ ．５ 年生存率。【结果】实验组与对照组近期总缓解率分别为５ ５ ％ 和２０ ％ ，２ ．５ 年生存率分别为２０ ％ 和０ ， 其差异有显著性（ Ｐ ＜ ０ ．０５） ；实验组 Ｓ Ａ 或 Ｃ Ａ１２５ 测定值下降，顺铂在体内维持时间 较长。【结论】采用足背淋巴管灌注化疗，有可能成 为治疗妇科癌症淋巴结转移有效、且副作用少的新方法。
【Objective】 To compare the clinical efficacy of lymphatic infusion chemotherapy (experimental group) and conventional radiotherapy or chemotherapy (control group) in the treatment of lymph node metastasis of gynecologic cancer. 【Methods】 Twenty patients were treated with high-dose single-time perfusion of dorsal lymphatic vessels. The levels of S A or C A 125 and plasma concentrations of cisplatin and imaging changes of lymph node metastases were determined before and after perfusion according to the patient’s disease status. And compared the conventional radiotherapy and chemotherapy, the patient’s short-term efficacy and 2. 5-year survival rate. [Results] The total remission rate in the experimental group and the control group was 55% and 20% respectively, 2. The 5-year survival rates were 20% and 0, respectively. The difference was statistically significant (P < 0.05). The experimental values of S A or C A-125 decreased, and the duration of cisplatin remained longer in the body. [Conclusion] The use of dorsal lymphovascular infusion chemotherapy may be a new method for the treatment of lymph node metastasis in gynecologic cancer with fewer side effects.