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本文报道了—种药代动力学模型,称之肾清除的全身前代谢的药动学灌注模型(或RPPP模型),用于阐明药物经吸收前、胃肠壁、肝首过性代谢和肾清除的时间过程。推导的公式
This paper reports a pharmacokinetic model called a pharmacokinetic perfusion model (or RPPP model) of whole body premetabolism of kidneys to clarify the effects of drugs on the gastrointestinal Clear time course. Derived formula