论文部分内容阅读
本文为探讨NET,NETO,NET-AC,NETO-AC,NGT和NGTO的抗着床原理,以体外培养方法研究了这六种甾体药物对离体人胎盘滋养层、蜕膜和大鼠离体卵巢颗粒细胞的形态学的直接影响。实验结果发现,当培养液内加入NET,NET-AC和NGT时对上述细胞无明显影响;当培养液内加入NETO,NETO-AC及NGTO的浓度为50μg/ml及100μg/ml时,在胎盘滋养层细胞培养过程中,可见细胞生长受抑制,细胞被破坏,其中以NGTO 100μg/ml作用更为明显。当NETO及NETO-AC的浓度为100μg/ml及NGTO的浓度为50μg/ml和100μg/ml时对离体蜕膜细胞也有损坏作用。六种甾体药物对大鼠离体卵巢颗粒细胞均无明显作用。
In order to explore the anti-implantation principle of NET, NETO, NETO-AC, NGT and NGTO, this study investigated the effects of these six steroid drugs on in vitro human placental trophoblast, decidua and rat Direct morphological effects of somatic ovarian granulosa cells. The results showed that when NET, NET-AC and NGT were added into the culture medium, there was no obvious effect on these cells. When the concentration of NETO, NETO-AC and NGTO was added to 50μg / ml and 100μg / ml, During trophoblast cell culture, cell growth was inhibited and cells were destroyed, with the effect of NGTO 100 μg / ml becoming more obvious. Detachment decidual cells were also damaged when the concentration of NETO and NETO-AC was 100μg / ml and that of NGTO was 50μg / ml and 100μg / ml. Six steroid drugs on rat ovarian granulosa cells had no significant effect.