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The levels of endometrial plasminogen activator were determined with Todd’s histochemical method in 85 women using IUD and 76 women without IUD as controls. It was found that the levels in all cases were bimodal, being high in the proliferative phase, lower in the secretory phase and highest in the premenstrual phase. The concentrations of plasminogen activator in the endometrium of IUD users complicated with menorrhagia were much higher than those in the IUD users with normal menstrual blood loss and in the controls during the proliferative, secretory and premenstrual phases. There was no difference in the concentrations of plasminogen activator between the IUD users with normal menstrual blood loss and the controls. The fluctuation of endometrial plasminogen activator levels during the different phases, and the uterine bleeding related to IUD are disscused.
The levels of endometrial plasminogen activator were determined with Todd’s histochemical method in 85 women using IUD and 76 women without IUD as controls. It was found that the levels in all cases were bimodal, being high in the proliferative phase, lower in the secretory phase and The concentrations of plasminogen activator in the endometrium of IUD users complicated with menorrhagia were much higher than those in the IUD users with normal menstrual blood loss and in the controls during the proliferative, secretory and premenstrual phases. There was no difference in the concentrations of plasminogen activator between the IUD users with normal menstrual blood loss and the controls. The fluctuation of endometrial plasminogen activator levels during the different phases, and the uterine bleeding related to IUD are disscused.