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目的:探讨银杏叶提取物与无创通气联合治疗重症支气管哮喘的疗效及其对患者肺功能、气道功能的影响。方法:将符合纳入标准的62例重症支气管哮喘患者随机分为对照组和治疗组各31例,对照组予基础治疗和无创双水平气道正压通气治疗,治疗组在对照组治疗基础上注射银杏叶提取物。比较两组患者治疗前后的肺功能指标、气道功能指标和气道炎性因子水平。结果:治疗后两组患者3项肺功能指标均升高,且治疗组高于对照组(P<0.05);IL-6和TNF-α水平下降,IL-10水平升高,治疗组患者各气道炎性因子水平优于对照组(P<0.05);治疗后两组患者4项气道功能指标均升高,且治疗组高于对照组(P<0.05)。结论:银杏叶提取物与无创通气联合治疗重症支气管哮喘有较好的疗效,有助于改善患者的肺功能,减轻气道高反应性和气道炎症。
Objective: To investigate the curative effect of ginkgo biloba extract combined with non-invasive ventilation on severe bronchial asthma and its effect on lung function and airway function. Methods: Sixty-two patients with severe bronchial asthma who met the inclusion criteria were randomly divided into control group and treatment group, with 31 cases in each group. The control group received basic therapy and non-invasive bi-level positive airway pressure ventilation. The treatment group was injected on the basis of the control group Ginkgo biloba extract. The lung function indexes, airway function indexes and airway inflammatory factors before and after treatment were compared between the two groups. Results: After the treatment, the three indexes of lung function in both groups were increased, and the treatment group was higher than the control group (P <0.05); the level of IL-6 and TNF-α was decreased and the level of IL-10 was increased. The levels of airway inflammatory cytokines were significantly higher than those of the control group (P <0.05). After the treatment, the four airway function indexes of the two groups were all higher than those of the control group (P <0.05). Conclusion: Ginkgo biloba extract combined with noninvasive ventilation in the treatment of severe bronchial asthma has a good curative effect, which can help to improve lung function, reduce airway hyperresponsiveness and airway inflammation.