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目的:探讨Ⅲ期乳腺癌改良根治术后患者复发转移的相关危险因素。方法:回顾性分析我院Ⅲ期乳腺癌患者192例的相关临床病理资料,就其与患者术后复发转移率的关系进行单因素和多因素分析。结果:192例患者的3年复发转移率为21.88%,单因素分析显示,3年复发转移率与年龄、术后放疗、术后规范化疗、病理类型、阳性淋巴结个数、雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体(HER2)有关(P<0.05);多因素非条件Logistic回归分析结果显示,术后放疗、术后规范化疗、病理类型、阳性淋巴结个数及ER、PR、HER2的表达是Ⅲ期乳腺癌改良根治术后发生复发转移的高危因素(P<0.05)。结论:术后放疗、术后规范化疗、病理类型、阳性淋巴结个数及ER、PR、HER2的表达是Ⅲ期乳腺癌改良根治术后发生复发转移的独立危险因素。
Objective: To investigate the risk factors of recurrence and metastasis in patients with stage Ⅲ breast cancer after modified radical mastectomy. Methods: The clinical and pathological data of 192 patients with stage Ⅲ breast cancer in our hospital were analyzed retrospectively. Univariate and multivariate analysis were performed on the relationship between them and the recurrence and metastasis rate. Results: The three-year relapse and metastasis rate of 192 patients was 21.88%. Univariate analysis showed that the recurrence and metastasis rate of 3-year and age, postoperative radiotherapy, postoperative standard chemotherapy, pathological type, the number of positive lymph nodes, estrogen receptor ER, PR, and HER2 (P <0.05). Multivariate Logistic regression analysis showed that postoperative radiotherapy, postoperative standard chemotherapy, pathological type, positive The number of lymph nodes and the expression of ER, PR and HER2 were the risk factors of recurrence and metastasis after modified radical mastectomy for stage Ⅲ breast cancer (P <0.05). Conclusion: The postoperative radiotherapy, postoperative standard chemotherapy, pathological types, the number of positive lymph nodes and the expression of ER, PR and HER2 are independent risk factors for recurrence and metastasis after modified radical mastectomy for stage Ⅲ breast cancer.