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实验用以氨基甲酸乙酯麻醉的大白鼠观察了电刺激饱中枢和摄食中枢对胃、盲肠及直肠运动的影响。刺激此二中枢在胃、盲肠及直肠均引起三种运动效应:亢进、抑制及“双相效应”。由刺激这些中枢引起的盲肠和直肠运动的效应通常与胃运动的效应相反。例如,刺激饱中枢引起胃运动的亢进和盲肠与直肠运动的抑制。由刺激饱中枢和摄食中枢引起的胃和盲肠运动的亢进效应被切断双侧迷走神经所完全消除。如切断双侧阴部神经丛的副交感支(PSB),直肠运动的亢进效应则不再出现。切断双侧迷走神经使胃和盲肠运动的抑制效应明显减弱,接着切断内脏大神经就使其残留的抑制效应完全消失。直肠运动的抑制效应被切断下肠系膜神经和 PSB 所完全消除。以上结果表明:饱中枢和摄食中枢不仅调节胃的运动而且也调节盲肠和直肠的运动;饱中枢和摄食中枢调节胃和盲肠运动的兴奋性冲动通过迷走神经传导,而其抑制性冲动则通过迷走神经和内脏大神经,但主要通过前者;到直肠的兴奋性冲动通过 PSB,而其抑制性冲动则通过下肠系膜神经和 PSB 传导。本文还用药理学方法探讨了引起胃肠道运动亢进效应和抑制效应的终端神经元的特性。
Experiments with urethane anesthetized rats observed the electrical stimulation of the full hub and feeding center on the stomach, cecum and rectal movement. Stimulation of the two centers in the stomach, cecum and rectum have caused three kinds of sports effects: hyperthyroidism, inhibition and “biphasic effect.” The effects of cecum and rectum movements caused by stimulation of these centers are often opposite to the effects of gastric motility. For example, stimulating the full center causes hyperthyroidism in the stomach and inhibition of the cecum and rectum. The hyperthyroidism effect of stomach and cecum motility caused by stimulation of the full central and feeding centers is completely eliminated by the interruption of bilateral vagal nerves. If cut off bilateral paranasal parasympathetic branch (PSB), rectal hyperactivity effect is no longer present. Cut off the bilateral vagus nerve so that gastric and cecal movement inhibitory effect was significantly weakened, then cut off the visceral nerve to make its residual inhibitory effect completely disappeared. The inhibitory effect of rectal motility is completely eliminated by the cleavage of the superior mesenteric nerve and PSB. The above results show that: the full central and feeding center not only regulate the movement of the stomach but also regulate the movement of the cecum and rectum; full of central and feeding center to regulate gastric and cecal movement excitability impulses through the vagus nerve conduction, and its inhibitory impulse through the vagus nerve Visceral nerves, but mainly through the former; excitatory impulses to the rectum pass through the PSB while their inhibitory impulses are transmitted through the inferior mesenteric nerve and PSB. This article also pharmacological methods to explore the effects of gastrointestinal motility and inhibitory effect of terminal neuronal characteristics.