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我们利用日本大耳白兔建立的输精管结扎1年吻合术5个月后的动物模型,分析了精子膜上腺嘌呤核苷脱氨酶(ADA)的活性以及该类精子膜上活性与受精能力之间的关系。实验结果显示吻合术5个月后,不孕组精子膜上ADA活性(186.87+63.73nMols/mgPro/h)明显高于孕组的ADA活性(132.81+49.85nMol/mgPro/h(P<0.01)。同时,两实验组ADA活性又高于对照组ADA活性(81.22+47.63nMol/mgPro/h)(P<0.01)。结果显示输精管结扎吻合后,精子膜上ADA活性明显升高是造成精子受精能力低下的原因之一。同时提示生殖道的病理变化将引致精子膜成分的变化。
We use the Japanese white rabbits established by vasectomy ligation anastomosis 5 months after the animal model of sperm membrane adenosine deaminase (ADA) activity and the type of sperm membrane activity and fertility The relationship between. The results showed that ADA activity (186.87 + 63.73nMols / mgPro / h) in the infertile group was significantly higher than that in the pregnant group (132.81 + 49.85nMol / mgPro / h) after 5 months of anastomosis (P <0.01) .At the same time, the activity of ADA in the two experimental groups was higher than that in the control group (81.22 + 47.63nMol / mgPro / h) (P <0.01) .The results showed that the ADA activity in the sperm membrane was significantly increased after the vasectomy and anastomosis, One of the reasons for low ability, while suggesting that pathological changes in the genital tract will lead to changes in sperm membrane composition.