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动植物的研究表明所有生活的机体均可被高压氧所伤害,由此而引起的机体损伤称为氧中毒。高压氧对机体的危害与暴露持续时间和强度有关,主要损伤肺和中枢神经系统。通常在一个大气压下,吸入60%以下的氧气,不会发生肺的损伤,但吸入100%的氧气,在几天内就会发生肺的氧中毒。肺泡壁毛细血管内皮和肺泡的Ⅰ型细胞破裂,间质水肿,肺泡表面透明膜形成,以后则有渗出,纤维组织和肺泡Ⅱ型细胞的增殖等反应发生。因而使肺的通气和换气功能发生障碍,导致严重的低氧血症。当吸入气中氧分压在2.5个大气压以上时,则首先引起中枢神经中毒症状,表现为肌肉抽搐、耳鸣、头昏、恶心、惊厥而神志常清楚。氧中毒机理还不完全明白,氧能加快化学反应的氧化过程,过量的氧能使许多酶和辅酶,特别是有疏基的酶和辅酶,因被氧化成氧化型而灭活。这可能是造成组织损伤的基础。在治疗低氧血症病人
Animal and plant research shows that all living organisms can be injured by hyperbaric oxygen, resulting in damage to the body called oxygen poisoning. Hyperbaric oxygen on the body and exposure duration and intensity related to the main damage to the lungs and central nervous system. Normally at one atmospheric pressure, inhalation of less than 60% oxygen does not cause lung damage, but 100% oxygen inhalation can cause lung oxygen poisoning within a few days. Alveolar capillary endothelial cells and alveolar type Ⅰ cell rupture, interstitial edema, alveolar surface of the transparent membrane formation, after exudation, fibrosis and alveolar type Ⅱ cell proliferation and other reactions. Thus impeding the ventilation and ventilation of the lungs, leading to severe hypoxemia. When the partial pressure of oxygen inhalation gas above 2.5 atm, then the first cause of central nervous symptoms, manifested as muscle convulsions, tinnitus, dizziness, nausea, convulsions and consciously always clear. Oxygen poisoning mechanism is not fully understood, oxygen can speed up the oxidation reaction of chemical reactions, excessive oxygen enables many enzymes and coenzymes, especially those with sparse groups of enzymes and coenzymes, due to be oxidized into oxidative and inactivated. This may be the basis for tissue damage. In the treatment of hypoxemia patients