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目的 研究血管内皮生长因子 (VEGF)在非小细胞肺癌 (NSCLC)中的表达及其临床意义。方法 应用链霉菌抗生物素蛋白—过氧化物酶 (SP)法染色技术测定 65例NSCLC组织标本的VEGF蛋白的表达水平 ,并分析其与病理类型、区域性淋巴结转移、肿瘤大小及病理分期之间的关系。结果 VEGF在NSCLC组织中表达的阳性率为 78 5% ,显著高于癌旁组织 ( 3 1% ) ;VEGF的表达与肿瘤大小有关 ,Φ≥ 5cm和 3 0≤Φ <5 0cm组的阳性率均显著高于Φ <3 0cm组 (P <0 0 5) ,但与病理类型、区域性淋巴结转移及病理分期无关 (P <0 0 5)。结论 检测VEGF的表达 ,有可能为判断NSCLC病变的发展以及评估预后提供依据。
Objective To study the expression of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC) and its clinical significance. Methods The expression of VEGF protein in 65 cases of NSCLC specimens was determined by streptavidin - peroxidase (SP) staining and analyzed with pathological types, regional lymph node metastasis, tumor size and pathological stage Relationship between. Results The positive rate of VEGF expression in NSCLC tissues was 78.5%, which was significantly higher than that in adjacent non-cancerous tissues (31.1%). The expression of VEGF correlated with tumor size, the positive rates of Φ≥5cm and 30≤Φ50cm (P <0.05), but it was not associated with pathological type, regional lymph node metastasis and pathological stage (P <0.05). Conclusion The detection of VEGF expression may provide a basis for judging the development of NSCLC lesions and assessing the prognosis.