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目的 研究乳腺癌腋窝淋巴结微小转移灶对预后的影响。方法 将 4 5例Ⅰ～Ⅱ期常规病理检查腋窝淋巴结转移阴性并随访 10年以上的原发性乳腺癌分成死亡和生存两组 ,以单克隆抗体细胞角蛋白 19为标志物 ,采用“准”连续切片免疫组化染色方法进行淋巴结微转移的回顾性对比研究。结果 死亡组的 2 5例中查出微转移 13例 ( 52 % ) ,生存组的 2 0例无 1例微转移检出 ,两组比较有极显著性差异 (P <0 0 1)。结论 本研究结果说明微转移严重影响病人预后 ,检查淋巴结微小转移灶具有理论与应用价值 ,“准”连续切片方法值得推广。
Objective To study the effect of micrometastasis in axillary lymph nodes of breast cancer on prognosis. Methods Forty-five cases of primary breast cancer with negative axillary lymph node metastasis and routine follow-up of more than 10 years were divided into death and survival groups. The monoclonal antibody cytokeratin 19 was used as a marker and “quasi” A retrospective, comparative study of lymph node micrometastasis by serial section immunohistochemical staining. Results Twenty-five micrometastases (52%) were detected in 25 cases of death group. There was no micrometastasis in 20 cases in survival group. There was significant difference between the two groups (P <0.01). Conclusion The results of this study indicate that micrometastasis has a serious impact on the prognosis of patients and the detection of micrometastases in lymph nodes has theoretical and practical value. The “quasi” serial sectioning method is worthy of promotion.