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目的观察吸烟与急性心肌梗死患者血脂水平和冠状动脉病变程度的相关性。方法选取129例急性心肌梗死患者为研究对象,参照国际公认的吸烟指数分级法将上述患者分为0级(43例)、1级(33例)、2级(31例)、3级(22例)四类患者,比较不同吸烟指数患者甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平变化,同时以Judkins法经股动脉进行选择性冠状动脉造影,观察不同吸烟指数患者冠状动脉病变支数情况。结果 0~3级吸烟患者TC、TG、LDL-C水平呈上升趋势(r=0.747、0.914、0.833,P<0.05),其中吸烟3级指数患者TG高于0、1级,而LDL-C高于0级,差异有统计学意义(P<0.05);吸烟指数1、2、3级指数患者三支病变发生率高于0级,差异有统计学意义(P<0.05/6);三支病变发生率随吸烟指数级别上升呈上升趋势(r=0.863,P<0.05)。结论吸烟可影响急性心肌梗死患者血脂水平,且吸烟指数越高,病变程度越严重,需引起临床重视。
Objective To observe the relationship between the level of lipid and the severity of coronary artery disease in smokers and acute myocardial infarction patients. Methods A total of 129 patients with acute myocardial infarction were enrolled in this study. According to the internationally accepted smoking index grading method, the above patients were divided into grade 0 (43 cases), grade 1 (33 cases), grade 2 (31 cases), grade 3 In this study, we compared the changes of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) Judkins method by femoral artery selective coronary angiography to observe the different smoking index patients with coronary artery lesion count. Results The levels of TC, TG and LDL-C in 0 to 3 smokers were increased (r = 0.747, 0.914, 0.833, P <0.05) (P <0.05). The incidence of three lesions in patients with smoking index 1, 2 and 3 index was higher than that of grade 0, the difference was statistically significant (P <0.05 / 6) The incidence of branch disease increased with the smoking index level (r = 0.863, P <0.05). Conclusion Smoking can affect the level of blood lipids in patients with acute myocardial infarction. The higher the smoking index, the more severe the disease, and the need for clinical attention.