论文部分内容阅读
原发性支气管肺癌(肺癌)是常见的恶性肿瘤,其发病率在世界各地呈上升趋势,其发病机制目前仍在探讨中。Ohta于1996年首次发现一种新的候选肿瘤抑制FHIT基因在机体许多部位的肿瘤中均有失活,很可能是一种在肿瘤发生中起重要作用的肿瘤抑制基因。本文采用RT-PCR方法检测原发性支气管肺癌中FHIT基因的缺失情况,初步探讨了FHIT基因的改变与肺癌的相互关系。此外,病毒致癌已成为新的研究热点,人们对人类乳头状瘤(HPV)的致癌作用的认识越来越深入。本实验检测了肺癌中的HPV感染情
Primary bronchial lung cancer (lung cancer) is a common malignancy, and its incidence in the world is on the rise, the pathogenesis is still under discussion. Ohta discovered for the first time in 1996 a new candidate tumor suppressor FHIT gene inactivation in many parts of the body of the tumor, most likely a tumor suppressor gene plays an important role in tumorigenesis. In this paper, RT-PCR was used to detect the deletion of FHIT gene in primary bronchogenic carcinoma, and the relationship between FHIT gene and lung cancer was discussed. In addition, viral carcinogenesis has become a new research hotspot, people’s understanding of the carcinogenic effect of human papillomavirus (HPV) deepening. This test detects HPV infection in lung cancer