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目的探讨肝硬化患者不同Child-Push肝功能分级与血清癌胚抗原CA125水平的关系。方法采用免疫化学发光法对20例正常人(对照组)和肝硬化Child分级A级、B级、C级的患者各20例检测血清CA125值,并用组间t检验比较对照组、肝硬化不同分级患者血清CA125值的相关性。结果肝硬化患者血清CA125水平显著高于正常对照组,并伴着肝硬化程度的加重而进行性升高。伴有腹水患者血清CA125水平与同Child-Pugh分级的无腹水患者相比明显升高,并随着腹水量的增加其CA125水平呈逐渐升高趋势。结论肝硬化患者血清CA125水平升高程度与肝功能损伤严重程度密切相关,血清CA125可作为肝硬化患者肝功能损害程度的参考指标,其水平高低可作预测预后的参考。
Objective To investigate the relationship between different Child-Push liver function grading and serum CA125 level in cirrhotic patients. Methods Serum CA125 levels were measured in 20 normal subjects (control group) and patients with grade A, B, and C of Child with liver cirrhosis by immunochemiluminescence. The levels of serum CA125 were detected by t-test. Correlation of serum CA125 values in grading patients. Results The serum level of CA125 in patients with cirrhosis was significantly higher than that in the normal control group, and increased progressively with the degree of cirrhosis. Serum CA125 levels in patients with ascites were significantly higher than those in patients with ascites without Child-Pugh classification, and the level of CA125 was gradually increased with the increase of ascites. Conclusions The level of serum CA125 in patients with cirrhosis is closely related to the severity of liver injury. Serum CA125 can be used as a reference index for the degree of liver damage in patients with cirrhosis. The level of serum CA125 can be used as a reference for predicting prognosis.