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目的观察临床应用卡托普利联合葛根素注射液与单独应用卡托普利治疗早期糖尿病肾病(DN)的疗效。方法将96例早期2型糖尿病(DM)患者随机分为观察组(54例)和对照组(42例),两组均常规降糖基础上治疗,观察组以卡托普利联合葛根素注射液治疗;对照组单独应用卡托普利治疗,比较两组治疗前后观察尿白蛋白(UAER)排泄率和肾功能(BUN,Cr)变化。结果两组治疗后UAER均较治疗前明显下降(P<0.05),且观察组UAER及肾功能改善幅度与对照组相比有显著性差异(P<0.05)。结论卡托普利和葛根素联合治疗早期DN,可明显降低微量白蛋白尿,改善肾功能,效果肯定。
Objective To observe the curative effect of captopril combined with puerarin and captopril alone on early diabetic nephropathy (DN). Methods Ninety-six patients with early type 2 diabetes mellitus (DM) were randomly divided into observation group (n = 54) and control group (n = 42). Both groups were treated with conventional hypoglycemic therapy. The observation group was treated with captopril and puerarin The control group was treated with captopril alone. The changes of urinary albumin (UAER) excretion rate and renal function (BUN, Cr) were compared before and after treatment. Results The UAER of both groups after treatment was significantly lower than that before treatment (P <0.05). There was significant difference between UAER and renal function in the observation group and the control group (P <0.05). Conclusion Captopril and puerarin combined treatment of early DN, can significantly reduce microalbuminuria, improve renal function, the effect is affirmed.