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通过对一已知反应速率盐效应的影响以及电解质的类型或存在与否的测定,使有可能洞察正在进行的化学反应的机制。此问题在β-内酰胺类抗生素分解动力学研究中,已引起人们的注意。观察速率常数(K_(obs))与离子强度(Ⅰ)间的关系可用其根和2~1+2~1来表示。本实验主要是以较多的实例,即以苯苄青霉素(1)及其α-氨基和α-叠氮化物衍生物[其中包括氨苄青霉素(2),羟氨苄青霉素(Amoxicillin,3)和迭氮西林(Azidocillin,4)、阿洛西林(Azlocillin,5)、美洛西林(Mezlocillin,6)和哌拉西林(Piperacillin,7)]作进一步的阐明。
By measuring the effects of salt effects on a known reaction rate and the type or presence of electrolyte, it is possible to gain insight into the mechanism of an ongoing chemical reaction. This problem has been drawing attention in the study of β-lactam antibiotic decomposition kinetics. The relationship between the observed rate constant (K_ (obs)) and ionic strength (I) can be expressed by its root and 2 ~ 1 + 2 ~ 1. This experiment is mainly based on a number of examples, namely, benzyl penicillin (1) and its α-amino and α-azide derivatives [including ampicillin (2), amoxicillin (Amoxicillin, Azidocillin (4), Azlocillin (5), Mezlocillin (6) and Piperacillin (7) were further elucidated.