论文部分内容阅读
目的 :探讨苯白血病患者 GSTμ 基因缺失频度 ,为进一步研究 GSTμ 基因缺失与苯白血病之间的关系寻找线索。方法 :采用聚合酶链反应 (Polymerase Chain Reaction,PCR)技术检测 GSTμ 基因型。结果 :苯白血病组 GSTμ 基因缺失率为 73.5 3% ,明显高于白血病组 (44 .44% )和对照组 (46 .88% ) (P<0 .0 1 )。苯白血病组的相对危险度为 3.1 5 ,说明在同样接触苯的情况下 ,GSTμ 基因缺失者患苯白血病的危险性是 GSTμ 基因携带者的 3.1 5倍。结论 :GSTμ 基因缺失可能是苯白血病的危险性因素之一。
Objective: To investigate the frequency of deletion of GSTμ gene in patients with leukemia, and to find clues for further study on the relationship between GSTμ gene deletion and leukemia. Methods: Polymerase Chain Reaction (PCR) was used to detect GSTμ genotypes. Results: The deletion rate of GSTμ gene was 73.5 3% in leukemia group, which was significantly higher than that in leukemia group (44.44%) and control group (46.88%) (P <0.01). The relative risk of leukemia was 3.1 5, indicating that in the same exposure to benzene, the risk of leukemia in patients with GSTμ gene deletion was 3.1 5 times higher than that in carriers of GSTμ gene. Conclusion: The deletion of GSTμ gene may be one of the risk factors of leukemia.