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郁胆在临床原非少见,但过去对它的概念认识不清。近十多年来,由于对胆汁生成、分泌的生理病理的研究、酶学的发展、动物实验和电镜检查,对郁胆有新的认识。许多学者认为肝内郁胆的基础是功能性的,摒弃了机械性阻塞的旧观点。所谓郁胆就是从肝细胞至奥狄氏括约肌这段通路胆汁的分泌和流量受到干扰或减少的结果。新概念的产生,必然影响到有关诊断和治疗。胆汁合成、分泌和肠肝循环的生理病理胆汁由胆盐、胆固醇、卵磷脂、有机阴离子(如胆红素、胆色素)和其他有机物质组成。胆盐是它的主要成份。胆固醇在肝细胞内的微粒体通过羟化作用
Depressed clinical non-rare, but in the past its concept is not clear. In the recent ten years, due to the physiological and pathological research on bile production and secretion, the development of enzymology, animal experiments and electron microscopy, have a new understanding of depression. Many scholars believe that the basis of intrahepatic cholera is functional, abandoned the old view of mechanical obstruction. The so-called depression is from the liver cells to the Oddi sphincter this passage of bile secretion and flow disturbances or reduced results. The emergence of new concepts will inevitably affect the diagnosis and treatment. Bile synthesis, secretion and enterohepatic circulation of the physical pathology bile by the bile salt, cholesterol, lecithin, organic anions (such as bilirubin, porphin) and other organic substances. Bile salt is its main ingredient. Cholesterol in the liver cells microsomes through hydroxylation