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阿霉素具较强抗各种肿瘤的活性,但有相当严重的心脏毒性。因此,监测血浆中阿霉素及其主要代谢物羟基阿霉素(Aol)很有必要。本文报道一种用于测定血浆中阿霉素及Aol浓度的荧光检测新HPLC法,与以前其它测定方法相比更为灵敏,适用于给药后长时间血药浓度的监测,以研究该药物的最后消除情况。色谱条件250mm×4mm id层析柱,内装8.5μm Lichrosorb RP,流动相为甲酸
Adriamycin with a strong anti-tumor activity, but there is a very serious cardiotoxicity. Therefore, the monitoring of doxorubicin in plasma and its main metabolite hydroxy doxorubicin (Aol) is necessary. This paper reports a new HPLC method for the determination of doxorubicin and Aol concentrations in plasma, which is more sensitive than previous assays and is suitable for the monitoring of prolonged plasma concentrations after administration to study the drug The final elimination. Chromatographic conditions 250mm × 4mm id column, containing 8.5μm Lichrosorb RP, the mobile phase is formic acid