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目的探讨预防剖宫产术后深静脉血栓形成的有效方法。方法选择2010年8月至2012年8月就诊于阜阳市人民医院产科的285例具有发生深静脉血栓高危风险的剖宫产术后产妇,随机分为治疗组及对照组,治疗组140例,于剖宫产术后24 h皮下注射低分子肝素钙5000 IU,每日1次,连续5 d;对照组145例,不使用低分子肝素及其他任何抗凝药物;术前及术后第4天监测凝血功能。结果治疗组无一例发生深静脉血栓,对照组发生4例下肢深静脉血栓,无1例肺栓塞,两组深静脉血栓发生率比较差异有统计学意义(P<0.05);治疗组术后D-二聚体及纤维蛋白原变化与对照组差异有统计学意义(P<0.05),两组患者出血倾向比较差异无统计学意义(P>0.05)。结论低分子肝素在预防剖宫产术后深静脉血栓形成方面效果确切,且无明显出血风险,有特异临床应用价值。
Objective To explore an effective method to prevent deep venous thrombosis after cesarean section. Methods A total of 285 pregnant women with caesarean section at risk of deep venous thrombosis at the Fuyang People’s Hospital from August 2010 to August 2012 were randomly divided into treatment group and control group. The treatment group (140 cases) Low-molecular-weight heparin 5000 IU was injected subcutaneously at 24 h after cesarean section, once a day for 5 consecutive days. In the control group, 145 low-molecular-weight heparin and no other anticoagulant drugs were used. Preoperative and postoperative 4 Day monitoring of coagulation. Results There was no deep venous thrombosis in the treatment group, 4 deep venous thrombosis in the control group, and no pulmonary embolism in the control group. There was significant difference in the incidence of deep venous thrombosis between the two groups (P <0.05) - dimer and fibrinogen changes and the control group, the difference was statistically significant (P <0.05), bleeding tendency between the two groups showed no significant difference (P> 0.05). Conclusion Low molecular weight heparin is effective in preventing deep venous thrombosis after cesarean section and has no obvious risk of bleeding and has specific clinical value.