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自身免疫性疾病是指因自身免疫反应而引起组织损伤的疾病。有的自身免疫性疾病已明确是自身抗体作用于自身抗原产生的自身免疫应答所致,有的尚难以证实。但是,在自身免疫疾病患者中能检查出自身抗体,这一点都是一致的。自从Friou等(1957)首先用间接免疫荧光法在系统性红斑狼疮病人血清中查出抗核抗体(ANA)以后,同年White又用同样的方法在桥本式甲状腺炎病人血清中,发现了抗甲状腺球蛋白抗体。相继又发现恶性贫血病人血清中有抗胃壁细胞抗体(Tayl-or等,1962),狼疮样肝炎病人有抗平滑肌
Autoimmune diseases are diseases caused by autoimmune reactions that cause tissue damage. Some autoimmune diseases have been clearly autoantibodies caused by autoantigen-induced autoimmune response caused by some still difficult to confirm. However, autoantibodies can be detected in patients with autoimmune diseases, which is consistent. Since Friou et al. (1957) first detected the antinuclear antibody (ANA) in the serum of patients with systemic lupus erythematosus by indirect immunofluorescence, the same method was used by White in the serum of Hashimoto’s thyroiditis patients Thyroglobulin antibody. Have also found in patients with pernicious anemia serum anti-parietal cell antibodies (Tayl-or et al, 1962), lupus-like hepatitis patients with anti-smooth muscle