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用小鼠对碘、氟在甲状腺肿、氟中毒发病中的联合作用进行了研究。105只雄性昆明种小鼠随机分为五组,即对照组、高氟Ⅰ组、高氟Ⅱ组、高碘组和高碘高氟组。研究发现:高Ⅰ、高碘、高碘高组之甲状腺重量均大于对照组(P<0.01);高碘及高碘高组之甲状腺6小时吸碘率低于其它各组(P<0.01),符合一般规律,但高碘高组之甲状腺吸碘率高于高碘组;实验第90天,碘交互作用对鼠门齿斑釉发病影响有显著性。提示:水源性高碘、高及高碘高均可引起甲状腺肿;高碘抑制甲状腺对碘的摄取,而高具有刺激甲状腺摄碘之趋势;高碘可以延缓的致斑牙作用。
The combined effects of iodine and fluoride on goiter and fluorosis in mice were studied. 105 male Kunming mice were randomly divided into five groups: control group, high fluoride Ⅰ group, high fluoride Ⅱ group, high iodine group and high iodine high fluoride group. The thyroid gland weight in high iodine group and high iodine high group were higher than those in the control group (P <0.01) , In line with the general law, but the high iodine high group of thyroid iodine absorption rate was higher than the iodine group; 90 days of experiment, iodine interaction on the incidence of rat gingival glaze glaze significant. Tip: high water-iodine, high and high iodine can cause goiter; high iodine inhibits the thyroid uptake of iodine, and high with the trend of thyroid uptake of iodine; iodine can delay the role of the cause of the plaque.