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目的:观察比较经鼻持续正压通气(NCPAP)与常规机械通气(CMV)对新生儿肺透明膜病的治疗效果、并发症发生及治疗费用情况,探讨有效且较经济的治疗方案。方法:将2003年9月～2009年7月确诊为Ⅰ、Ⅱ级肺透明膜病的78例早产儿随机分为A、B两组,A组36例为CMV组,B组42例为NCPAP组,两组基础治疗相同。结果:A组治愈率91.67%,B组治愈率90.48%,两组比较差异无统计学意义(P>0.05)。但B组发生呼吸机相关性肺炎、呼吸机所致肺损伤等并发症明显少于A组且治疗费用亦较A组低。结论:NCPAP治疗肺透明膜病疗效可靠,并发症相对少,操作简便,费用低廉,尤其适合在广大基层医院推广应用。
Objective: To compare the therapeutic effects, complications and costs of nasal continuous positive pressure ventilation (NCPAP) and conventional mechanical ventilation (CMV) on neonatal hyaline membrane disease and to explore effective and economical treatment. Methods: Seventy eight preterm infants diagnosed with grade Ⅰ and Ⅱ hyaline membrane disease from September 2003 to July 2009 were randomly divided into A and B groups, 36 cases in group A were CMV group and 42 cases in group B were NCPAP Group, two groups of basic treatment the same. Results: The cure rate of group A was 91.67%, while that of group B was 90.48%. There was no significant difference between the two groups (P> 0.05). However, B group had ventilator-associated pneumonia, ventilator-induced lung injury and other complications were significantly less than the A group and treatment costs are also lower than the A group. Conclusion: NCPAP treatment of hyaline membrane disease with reliable curative effect, relatively fewer complications, simple operation, low cost, especially for the promotion and application of the majority of primary hospitals.