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本文介绍了作者在近几年内对人工细胞在胰岛移植、肝衰及肾衰中的研究情况。在胰岛组织外包裹一层特殊的人工膜,可以允许透过膜岛索及营养液,但大分子量免疫球蛋白却不能透入,起到免疫隔离作用,且胰岛组织在微囊人工膜内生长良好,并不断分泌胰岛素,故解决了组织移植时的排异反应;在吸附剂外包裹一层膜,可以改善生物相容性,但在活性碳血液灌流时能短暂地削弱机体免疫防御机能。在应用人工细胞包膜吸附剂治疗肝衰时,还研究了其对甲状腺激素及皮质醇的吸附情况。在肾衰时活性碳血液灌流可以清除有害的中分子量物质;应用人工细胞酪氨酸固相酶血液灌流可以选择性地降低与肝性脑病发病机制有空的过高的血浆酪氨酸及游离酚。
This article describes the author in recent years on artificial cells in islet transplantation, liver failure and renal failure research. In the islet tissue wrapped with a layer of special artificial membrane that can allow the membrane through the island cable and nutrient solution, but the large molecular weight immunoglobulin can not penetrate, play a role in immune isolation, and islet tissue in the microcapsule artificial membrane growth Good, and continue to secrete insulin, so to solve the rejection of tissue transplant rejection; wrapped in a layer of membrane adsorbent can improve the biocompatibility, but in the activated carbon during blood perfusion can weaken the body’s immune defense function. In the application of artificial cell-coated adsorbent for the treatment of liver failure, its adsorption of thyroid hormone and cortisol was also studied. Activated charcoal hemoperfusion in renal failure can remove harmful substances in the middle molecular weight; application of artificial cytosolic tyrosine enzyme in vivo hemoperfusion can selectively reduce the pathogenesis of hepatic encephalopathy with excessive empty of plasma tyrosine and free phenol.