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扑热息痛又名醋氨酚,是非甾体类的解热镇痛药,作为非那西汀的安全替代药以单剂或制成复方制剂广为应用,其各种复方制剂在国外已达20余种。本品解热作用与阿司匹林相似,镇痛作用则较后者弱。口服吸收迅速、完全,服后30～60分钟血药浓度达高峰,对胃肠道刺激小,无诱发消化性溃疡及出血的缺点。常用剂量短期服用,无不良反应,即使已有肝病的患者服用,也无明显的毒副作用。但大剂量扑热息痛(单剂15克或每日5～8克用几周)可引起严重的肝脏损害甚至死亡。急性超剂量后的第1个毒性信号大约出现在
Paracetamol, also known as acetaminophen, is a non-steroidal antipyretic and analgesic drug. As a safe alternative to phenacetin, it has been widely used in single or multiple drug formulations. Its various compounds have reached more than 20 in foreign countries Species. This product antipyretic effect and aspirin similar analgesic effect is weaker than the latter. Oral absorption quickly and completely, after serving 30 to 60 minutes peak plasma concentration, gastrointestinal stimulation, no induced peptic ulcer and bleeding shortcomings. Short-term use of commonly used doses, no adverse reactions, even if patients with liver disease taking, there is no obvious side effects. However, high doses of paracetamol (15 grams for a single dose or 5 to 8 grams for several weeks) can cause severe liver damage and even death. The first toxic signal appeared after acute overdose