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目的:了解浙江省11家医院2010~2014年肺癌患者麻醉药品的使用情况及用药趋势,为麻醉药品临床合理应用提供参考。方法:抽取浙江省11家医院2010~2014年肺癌患者的医嘱,对麻醉药品的用药金额、用药频度(DDDs)、限定日费用(DDC)、排序比以及口服缓控释制剂与贴剂用量比值进行分析。结果:浙江省11家医院肺癌患者2010~2014年抽样医嘱中药品消耗总金额与麻醉药品销售金额均逐年增加,麻醉药品金额构成比也逐年增加,5年来麻醉药品金额构成比增加了81.34%。2010~2014年盐酸羟考酮缓释片销售金额、DDDs均有显著增加,为目前最常用的缓控释麻醉药品。即释吗啡销售金额及DDDs也呈明显上升趋势,一定程度上表明疼痛滴定和爆发痛解救合理性有所上升。此外,缓控释制剂中口服与贴剂用量比值逐步升高,符合WHO首选口服的癌痛治疗理念。结论:浙江省11家医院肺癌患者2010~2014年抽样医嘱中麻醉药品的使用不断趋于合理,麻醉药品用于癌痛治疗的规范性有所提升。
Objective: To understand the use of narcotic drugs and the trend of drug use in 11 patients with lung cancer from 11 hospitals in Zhejiang Province from 2010 to 2014, and to provide reference for the clinical application of narcotic drugs. Methods: The prescriptions of lung cancer patients from 2010 to 2014 in 11 hospitals of Zhejiang Province were collected. The dosage of narcotic drugs, the DDDs, the DDC, the ranking ratio and the dosage of oral controlled release and patch Ratio analysis. Results: The total amount of medicine consumed and the sales amount of narcotic drugs in lung cancer patients from 11 hospitals in Zhejiang Province during 2010-2014 increased year by year. The composition ratio of narcotic drugs also increased year by year. The composition ratio of narcotic drugs in the past five years increased by 81.34%. From 2010 to 2014 oxycodone hydrochloride sustained release tablets sales amount, DDDs have increased significantly, is currently the most commonly used controlled release narcotic drugs. Simvastatin sales volume and DDDs also showed a clear upward trend, to some extent, indicating that pain titration and outbreak of pain relief rationality has increased. In addition, the controlled release preparation of oral and patch dosage ratio gradually increased, in line with WHO preferred oral cancer treatment concept. Conclusion: The use of narcotic drugs in sample orders from 2010 to 2014 in 11 hospitals in Zhejiang Province is becoming more and more reasonable. The standard of narcotic drugs for the treatment of cancer pain has been improved.