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扶正解毒煎剂为抗肿瘤治疗的辅助性中药制剂。本实验从体内和体外两方面研究扶正解毒煎剂和环磷酰胺对正常及荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的影响。结果表明:在体外,大肠杆菌脂多糖有诱生肿瘤坏死因子的作用。相反,扶正解毒煎剂和环磷酰胺不但无诱生肿瘤坏死因子的作用,而且抑制脂多糖的诱生。在体内,环磷酰胺对荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的功能无明显影响。而扶正解毒煎剂则有明显增强经环磷酰胺治疗的荷瘤小鼠腹腔巨噬细胞产生肿瘤坏死因子的功能。
Fuzhengjiedu decoction is an auxiliary traditional Chinese medicine preparation for antitumor therapy. In this experiment, the effects of Fuzheng Jiedu decoction and cyclophosphamide on tumor necrosis factor production in normal and tumor-bearing mouse peritoneal macrophages were studied in vivo and in vitro. The results showed that: in vitro, E. coli lipopolysaccharide induced tumor necrosis factor. In contrast, Fuzhengjiedu decoction and cyclophosphamide not only did not induce the effect of tumor necrosis factor, but also inhibited the induction of lipopolysaccharide. In vivo, cyclophosphamide had no significant effect on tumor necrosis factor production in peritoneal macrophages of tumor-bearing mice. The Fuzhengjiedu decoction significantly enhanced the function of tumor necrosis factor produced by peritoneal macrophages of tumor-bearing mice treated with cyclophosphamide.