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目的:分析肠杆菌科菌株对碳青霉烯类抗菌药物的耐药性,为临床合理使用碳青霉烯类抗菌药物所提供参考。方法:选取2015年9月—2016年9月间分离出的25株肠杆菌科菌株,采用改良后的Hodge实验法对菌株进行药敏试验和鉴定,分析其对碳青霉烯类抗菌药物的耐药情况。结果:肠杆菌科菌株对多黏菌素敏感,其敏感率为100.00%;对阿米卡星和复方磺胺甲噁唑敏感率依次为76.40%和68.20%;而对氨苄西林、头孢菌素和亚胺培南的耐药性均为100.00%;对美罗培南的耐药性为87.40%;经Hodge检测阳性率为84.00%。结论:碳青霉烯类抗菌药物对肠杆菌科菌株在临床上均表现为多重且高度耐药性。
OBJECTIVE: To analyze the drug resistance of Enterobacteriaceae to carbapenem-based antibiotics and to provide a reference for the rational use of carbapenem-based antibiotics in clinic. Methods: 25 strains of Enterobacteriaceae isolated from September 2015 to September 2016 were selected. The susceptibility test and identification of the strains were carried out by the modified Hodge test. The effects of carbapenem antibiotics Drug resistance. Results: The susceptibilities of Enterobacteriaceae to polymyxin were 100.00%. The susceptibilities to amikacin and sulfamethoxazole were 76.40% and 68.20%, respectively. While for ampicillin, cephalosporin and The resistance of imipenem was 100.00%. The resistance to meropenem was 87.40%. The positive rate of hyaluronan was 84.00%. CONCLUSION: Carbapenem antibacterials are clinically multiple and highly resistant to Enterobacteriaceae strains.