A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

• 作 者: Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey L.Wrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takas
• 机 构: Department of Orthopaedic Surgery,Osaka University Graduate School of Medicine,2-2 Yamadaoka,Suita,O
• 出 处: 骨研究（英文版）
• 发表日期: 2020年4期

INTRODUCTIONrnTransforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) play important roles in bone metabolism.1–3 Genetic mutations in TGF-βor BMP signaling pathway components cause heritable developmental bone diseases, and dysregulation of TGF-β or BMP signaling is often associated with osteoporosis or osteoarthritis.