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目的探讨环磷酰胺冲击联合激素治疗难治性肾病综合征疗效。方法选取我院2008年6月至2011年6月80例难治性肾病综合征患者,将其随机分成对照组和研究组,每组患者40例,对照组使用常规激素治疗,研究组实施环磷酰胺冲击并激素联合治疗,观察对比两组患者临床效果、不良反应等。结果研究组40例患者,26例完全缓解,12例部分缓解,未缓解1例;对照组40例患者,完全缓解16例,部分缓解18例,12例无效。和对照组总有效率(85%)比较研究组总有效率(95%)明显要高,有统计学意义(P<0.05)。研究组中,有2例患者发生胃肠道不良反应,通过给予对症治疗,其症状有明显缓解;对照组中,4例患者发生呼吸道感染疾病,4例发生胃肠道不良反应,通过对症治疗,其症状得到有效缓解。和对照组(5%),研究组不良反应产生率(20%)要降低很多,有统计学意义(P<0.05)。结论治疗难治性肾病综合征时,环磷酰胺冲击联合激素疗效显著,且临床不良反应较少。
Objective To investigate the effect of cyclophosphamide combined with hormones in the treatment of refractory nephrotic syndrome. Methods 80 patients with refractory nephrotic syndrome in our hospital from June 2008 to June 2011 were randomly divided into control group and study group, 40 patients in each group, the control group using conventional hormone therapy, the study group implementation of the ring The impact of phosphoramidite and hormone combination therapy, observation and comparison of two groups of patients clinical effects, adverse reactions. Results In study group 40 patients, 26 patients were completely relieved, 12 patients partially relieved and 1 patient did not relieve. In control group, 40 patients were completely relieved 16 patients, partially relieved 18 patients and 12 patients ineffective. The total effective rate (85%) in the control group was significantly higher than that in the control group (95%), with statistical significance (P <0.05). In the study group, 2 patients experienced adverse reactions of the gastrointestinal tract. Symptoms were relieved by symptomatic treatment. In the control group, 4 patients developed respiratory tract infection and 4 patients had gastrointestinal adverse reactions. Through symptomatic treatment , The symptoms have been effectively alleviated. And control group (5%), the incidence of adverse reactions in study group (20%) was much lower, with statistical significance (P <0.05). Conclusion The treatment of refractory nephrotic syndrome, cyclophosphamide shock combined hormones significant effect, and less clinical adverse reactions.